Supported by funding from the National Institutes of Health (NIH), Yale School of Medicine is a leading hub for a network of medical institutions in the Northeast, working with 12 other major centers across the United States. United. The network conducts clinical trials designed to advance the science of emergency care, improving outcomes for patients suffering from neurological, cardiac, respiratory, hematological and traumatic emergencies. It is a unique field of medicine due to the high stakes and time constraints for patients who suddenly need emergency treatment.
“Will the patient survive? And if they survive, will they survive with a return to a functional state, or will they be severely disabled? asks Gail D’Onofrio, MD, Albert E. Kent Professor of Emergency Medicine and Professor of Epidemiology (chronic diseases) and Medicine (addictions). “It’s in those first minutes and hours that interventions can make a major difference in someone’s life.”
Called SIREN (“Strategies to Innovate EmeRgENcy Care Clinical Trials Network”), the collaboration tests emergency interventions for life-threatening illnesses and injuries, which are rare enough that sufficient data can only come from encounter assessments in several institutions. “Access to large and diverse populations is essential to properly test these interventions,” says D’Onofrio, who will be the principal investigator of the Yale hub, which is called Yale-METRO (Metropolitan Emergency Trial Network to advance patient Outcomes). The trials will cover the full spectrum of pre-hospital, emergency department and hospital care through long-term follow-up and rehabilitation. The results of these trials will inform clinical care and standards of practice in the future. Several emergency medicine physician-researchers, including Charles Wira, MD; Richard Andrew Taylor, MD, MHS; and Basmah Safdar MD, MSc, play an important role in the project.
Yale New Haven Hospital, one of the largest in the nation with more than 1,500 beds, is adding a significant number of potential patients who can enroll in the trials. And Yale’s extensive expertise in emergency medicine, cutting-edge technology at its disposal, and the collaborations and experience of its intensivists, neurosurgeons, neurologists, cardiologists, and trauma surgeons provide unique opportunities to bring great value and innovation to the project.
Yale School of Medicine’s participation will be a multidisciplinary collaboration between the departments of emergency medicine and neurology. Kevin Sheth, MD, professor of neurology and neurosurgery, has a proven track record as the principal investigator of two NIH multicenter neuroscience networks, NeuroNEXT and StrokeNet, which have recruited new and large patient populations rich in ethnic and racial diversity . Sheth, who is also vice president of clinical and translational research in neurosurgery and neurology, says his specialties and emergency medicine are closely linked, something the NIH’s National Institute of Neurological Disorders and Stroke acknowledges. more and more.
“When we think of neurology, we rightly think of chronic ambulatory diseases: Parkinson’s, Alzheimer’s, migraines. However, there is another set of neurological diseases that are common and fatal, including strokes, head injuries, seizures and brain infections like meningitis,” he explains. “These are emergencies, so they intimately involve collaborations with the prehospital system and they often present and take place in emergency departments.” Sheth also notes D’Onofrio’s expertise in the field of substance abuse and addiction, another area where neurology and emergency medicine intersect, with psychiatry. Other team leaders in the Department of Neurology include Emily Gilmore, MD, and Rachel Beekman, MD.
Teams from these departments and other departments at Yale have already been working together for years, Sheth says. This made Yale a particularly strong candidate to join this group of clinical trials. Membership also promises to strengthen Yale by providing new opportunities for young scholars to develop their knowledge and skills.
“I’m especially thrilled,” says Sheth, “because YaleMETRO represents an exciting collaboration with Yale’s new interdisciplinary Center for Brain and Mind Health, which aims to bring clinically cutting-edge neuroscience research to our communities. relevant. Sheth is one of the directors of the new center.
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